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Tofacitinib also significantly inhibits IL-22-induced CXCL1 and CXCL5 expression in human colonic tissues, suggesting that targeting the IL-22/CXC chemokine axis through JAK/STAT inhibition may be a viable therapeutic strategy

For example, carvacrol upregulates GPX4 expression to slow the progression of lipid peroxidation, thereby inhibiting ferroptosis and showing potential for treating cerebral ischemia [124]

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